EC-102: Stereochemistry and Thermo -analytical Methods
M.M.: 35
Unit-I: Stereochemistry-I
(a) Conformational analysis: Conformation of n-butane and cyclohexane, stability of conformers and energy profile diagram.
(b) Optical activity: Criteria for optical activity, stereoisomers, enantiomers and diastereomers, erythro and threo isomers, a general idea of symmetry elements.
Unit-II: Stereochemistry-ll
(a) Racemic Modifications: Conglomerate, racemate and racemic solid solutions, a general idea of stereo selective synthesis.
(b) Resolution of Racemic modifications: by Chemical separation, chromatography, preferential crystallization and asymmetric transformation (a brief idea only).
Unit-III: Statistical Treatment of Data
Types of errors, accuracy and precision, rounding off, significant figures, normal distribution of errors, statistical treatment of finite samples (mean, median, range & average deviation), t-test, confidence interval of the mean, standard error of a mean, test of significance, comparison of two means, F-test, rejection of data, Q-test, bivariate data, Quality control charts, relationship between variables, correlation & regression, principle of least squares. Standardization of analytical methods.
Unit-IV: Thermo-analytical Methods
Thermogravimetry, factors affecting thermogravimetric curves, derivative thermogravimetry (DTG), thermobalances, applications of thermogravimetry, differential thermal analysis, factors affecting DTA curve, instrumentation, applications of DTA.
Differential scanning calorimetry, theory, instrumentation, applications of DSC, thermometric titration, principle, classification, instrumentation and applications of thermometric titration.
Unit-V: Principles of Gravimetric Analysis
Stoichiometry of gravimetric reactions, formation and properties of precipitates, precipitation from homogeneous solution, nucleation, organic precipitations, applications of gravimetric analysis.
Books Recommended
1. D.A. Skoog, F.J. Holler and Nieman, Principles of Instrumental Methods, 5th ed.,Thomson Asia Pvt.
Ltd., Singapore (2003).
2. R.A. Day and A.L. Underwood, Quantitative Analysis, 6th ed., Prentice Hall of India Pvt. Ltd. (1993).
3. G.D. Christian., Analytical Chemistry, 6th ed, John Wiley & Sons (2000)
4. A.I. Vogel, Textbook of Quantitative Chemical Analysis, 5th ed., Addison Wesley Longman
Singaporepte Ltd. (1999)
5. G. W. Eving, Instrumental Methods of Chemical Analysis, 5th ed.,,Mc-Graw Hill Book Company
(1985)
6. Ernest L. ELiel and Samuel H. Wilen,Stereochemistry of Organic Compounds , John Wiley & Sons (2003).
